Small‐Molecule Inhibition of Glucose Transporters GLUT‐1–4

Glucose transporters in obesity

L’obCsitC, pathologie frtquente dans les sociCtCs industrialiskes, est caractQiste par un sur-diveloppement du tissu adipeux. Nous avons CtudiC un moditle animal d’obksitk, le rat Zucker gCnCtiquement obkse. D b l’iige de 30 jours, les cellules adipeuses des rats mutants transportent beaucoup plus de glucose que celles des temoins normaux des memes portCes. Cette anomalie repose sur une augment...

Targeting of mammalian glucose transporters.

Glucose transporters in preimplantation development.

The inability of the embryo to utilize glucose as a fuel before compaction has been an area of much speculation. It is suggested that limitations in glucose transporter processes are the prime reasons for this. The recent identification of GLUT3 as the transporter responsible for the uptake of maternal glucose after compaction may provide the missing link in this puzzle. Furthermore, the coinci...

Glucose transporters in mammalian brain.

(;lucose is the primary energy source for mammalian brain and a continuous supply is vital for normal cerebral function. At rest, the brain is responsible for metabolizing up to 60% of the available circulating glucose, and the efficient transport of glucose across the blood-brain barrier (BRH) and into the various cells that make up the brain is essential. Of the six facilitative glucose trans...

Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer.

Melatonin is present in a multitude of taxa and it has a broad range of biological functions, from synchronizing circadian rhythms to detoxifying free radicals. Some functions of melatonin are mediated by its membrane receptors but others are receptor-independent. For the latter, melatonin must enter into the cell. Melatonin is a derivative of the amino acid tryptophan and reportedly easily cro...